Pall Corporation

Full Adeno Associated Virus (AAV) Capsid Enrichment Using Mustang® Q Membrane

Recommendations for this critical process step


The newly extended range of Mustang Q XT membrane chromatography capsules is ideally suited to gene therapy applications as it is not limited by diffusion, unlike traditional resins. This means that for large target molecules, such as viruses or plasmids, there is more available surface area for binding, resulting in higher capacities and a faster purification process.

This application note will help process development scientists optimize the purification step to separate empty and full AAV capsids and achieve:
  • Complete separation of empty and full capsids
  • A purification process that takes less than 30 minutes
  • Faster process development by monitoring and optimizing the process in real time
Mustang Q XT capsules are ready and easy to use, and are a fast, scalable, and cost-effective purification step for virus production.


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